Absolutely . . . depending on which gutter guards you have installed. Many gutter guard types sold at big box stores barely suffice as a break even investment due to their poor design and quality.
If a homeowner has their gutters cleaned twice a year at $150 per cleaning, they will have paid $3000 over a decade and have little to show for the money spent. Having the best gutter guards installed however, eliminates gutter cleaning entirely and often last for the life of your gutter, easily recouping your investment.